Dr. Jane Churpek is a translational physician-scientist and genetic hematologist specializing in hereditary hematologic disorders and cancer predisposition syndromes. Her research focuses on identifying inherited genetic factors that increase the risk of cancer and bone marrow disorders, particularly among understudied populations. By investigating how genetic predisposition interacts with environmental exposures, her work aims to improve early detection, treatment, and prevention strategies.

Her laboratory employs genomic approaches using human population and family-based studies to uncover novel hereditary risk factors, alongside cellular and mouse models to define disease mechanisms. She has contributed to the identification of several novel hereditary blood cancer predisposition syndromes and has advanced the understanding of inherited susceptibility in exposure-associated cancers such as therapy-related leukemia and mesothelioma.